Association of O - antigen serotype with the magnitude of initial systemic cytokine 1 responses and persistence in the urinary tract 2 3 Running title : LPS Serotype , cytokine modulation and persistence 4 5
نویسندگان
چکیده
Association of O-antigen serotype with the magnitude of initial systemic cytokine 1 responses and persistence in the urinary tract 2 3 Running title: LPS Serotype, cytokine modulation and persistence 4 5 Dennis J. Horvath Jr., Ashay S. Patel, Ahmad Mohamed, Douglas W. Storm, 6 Chandra Singh, Birong Li, Jingwen Zhang, Stephen A. Koff, Venkata R. 7 Jayanthi, Kevin M. Mason, Sheryl S. Justice 8 9 The Research Institute at Nationwide Children’s Hospital, Columbus, Ohio 10 Nationwide Children’s Hospital, Columbus, Ohio 11 The Ohio State University School of Medicine, Columbus, Ohio 12 #Correspondence: Sheryl S. Justice, Center for Microbial Pathogenesis, The Research 13 Institute at Nationwide Children’s Hospital, 700 Children’s Drive, Columbus OH, 43205 14 [email protected] 15 16
منابع مشابه
Comparision of the effects of Leishmania Soluble Antigen (LSA) and Lipopolysaccharide (LPS) on C57BL/6 Mice Macrophage Function
Background: Macrophages activation is the important anti-leishmania immune response. Different signals could affect macrophages development and functional activation. Objectives: In the present study, we compared the effect of Leishmania Soluble Antigen (LSA)and Lipopolysaccharide (LPS) on peritoneal macrophage responses. Appropriate activation of macrophages depends on thesignals they receive ...
متن کاملEffect of Shiga Toxin And Its Subunits On Cytokine Induction in Different Cell Lines
Shiga toxins (Stxs) are bacterial virulence factors produced by Shigella dysenteriae serotype 1 and Escherichia coli strains. Stxs are critical factors for the development of diseases such as severe bloody diarrhea and hemolytic uremic syndrome. Additionally, Stxs trigger the secretion of pro- inflammatory cytokines and chemokines, particularly in monocytes or macrophages. The inflammatory cyto...
متن کاملAnalysis of Salmonella enterica serotype-host specificity in calves: avirulence of S. enterica serotype gallinarum correlates with bacterial dissemination from mesenteric lymph nodes and persistence in vivo.
Host and bacterial factors that determine whether Salmonella serotypes remain restricted to the gastrointestinal tract or penetrate beyond the mucosa and cause systemic disease remain largely undefined. Here, factors influencing Salmonella host specificity in calves were assessed by characterizing the pathogenesis of different serotypes. Salmonella enterica serotype Dublin was highly virulent i...
متن کاملSerotype-dependent response of human dendritic cells stimulated with Aggregatibacter actinomycetemcomitans.
AIM Different serotypes of Aggregatibacter actinomycetemcomitans have been described based on the lipopolysaccharide (LPS)-O-polysaccharide antigenicity. In turn, a distinct effect of A. actinomycetemcomitans serotypes has been described on cell proliferation and pro-inflammatory cytokine production in different human cells. This study was aimed to investigate the differential dendritic cell (D...
متن کاملEscherichia coli lipopolysaccharides produce serotype-specific hypothermic response in biotelemetered rats.
We investigated whether LPS-induced hypothermia develops in a serotype-specific manner in biotelemetered conscious rats. Two different Escherichia coli serotypes of LPSs were injected at a dose of 250 mug/kg ip. E. coli O55:B5 LPS elicited an initial hypothermia and subsequent fever, but E. coli O111:B4 LPS caused more potent monophasic hypothermia. Serum tumor necrosis factor (TNF)-alpha level...
متن کامل